Third generation oral contraceptives-- the controversy
نویسندگان
چکیده
منابع مشابه
Third generation oral contraceptives and vascular risks.
Third generation oral contraceptives (OC), containing the progestins desogestrel and gestodene, were introduced in the 1980s in a attempt to lower the risk of cardiovascular side effects. However, the observation that desogestrel and gestodene in combined OC were related to a 50 to 100% greater risk of venous thromboembolism (VTE) suggested that the issue is more complex than originally thought...
متن کامل[Third generation oral contraceptives and risk of venous thrombosis].
OBJECTIVE To evaluate quantitatively articles that compared effects of second and third generation oral contraceptives on risk of venous thrombosis. DESIGN Meta-analysis. STUDIES Cohort and case-control studies assessing risk of venous thromboembolism among women using oral contraceptives before October 1995. MAIN OUTCOME MEASURES Pooled adjusted odds ratios calculated by a general varian...
متن کاملcomparing the effects of the second-and third-generation oral contraceptives on sexual functioning
abstract background: the aim of this study was to compare the effects of the second- and third-generation oral contraceptives on women’s reproductive sexual function. materials and methods: this randomized, double-blind, placebo-controlled clinical trial was conducted on 82 married women of reproductive age in tehran. samples were randomized into the groups receiving second- and third-generatio...
متن کاملEnd of the line for "third-generation-pill" controversy?
Through modification of an in vitro test for thrombosis formation, a Dutch research group has made three significant findings: 1) third-generation oral contraceptives (OCs) induce a resistance to the blood's natural anticoagulation system of a magnitude close to that induced by a mutation in coagulation factor V Leiden; 2) second-generation OCs show only part of the effect; and 3) in OC users h...
متن کاملMyocardial infarction and third generation oral contraceptives: aggregation of recent studies.
BACKGROUND Arterial cardiovascular and cerebrovascular adverse events associated with oral contraceptives (OC) are a major concern to the clinician. This paper aggregates the findings of seven recent oral contraceptive studies on the risk of acute myocardial infarction (MI) among users of second (2gen) and third (3gen) generation OC. METHODS Odds ratios (OR) from seven original studies publis...
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ژورنال
عنوان ژورنال: BMJ
سال: 1995
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.311.7020.1589